Kinetin riboside

CAS No. 4338-47-0

Kinetin riboside ( N6-Furfuryladenosine;FAdo )

Catalog No. M14476 CAS No. 4338-47-0

A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 27 In Stock
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Biological Information

  • Product Name
    Kinetin riboside
  • Note
    Research use only, not for human use.
  • Brief Description
    A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.
  • Description
    A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines; inhibits MiPaCa-2 cell proliferation with IC50 of 0.27 uM; induceds marked suppression of CCND2 transcription and rapidly suppresses cyclin D1 and D2 protein expression in primary myeloma cells and tumor lines, causing cell cycle arrest, tumor cell-selective apoptosis, and inhibition of myeloma growth in xenografted mice; also can activate PINK1 in cells independent of mitochondrial depolarization.
  • Synonyms
    N6-Furfuryladenosine;FAdo
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4338-47-0
  • Formula Weight
    347.33
  • Molecular Formula
    C15H17N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=CO4)N=CN=C23)O[C@H](CO)[C@H]1O
  • Chemical Name
    Adenosine, N-(2-furanylmethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Osgerby L, et al. J Med Chem. 2017 Apr 27;60(8):3518-3524.
2. Tiedemann RE, et al. J Clin Invest. 2008 May;118(5):1750-64.
3. Hertz NT, et al. Cell. 2013 Aug 15;154(4):737-47.
4. Choi BH, et al. J Biol Chem. 2010 Mar 26;285(13):9770-9.
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